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Method and Reagent for Decarboxylative Functionalization of Carboxylic Acids

Technology #19-0131

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Researchers
Erik Alexanian
Managed By
Chance Rainwater
Commercialization Manager 919.445.9371
Patent Protection
Provisional Patent Application Filed

A method and associated reagent for direct decarboxylative functionalization of aliphatic compounds via photo-induced hydrogen atom transfer has been developed.  This method provides a new route for late-stage modification of natural products, biological compounds, and drugs through introduction of a xanthyl group that is further elaborated into a variety of derivatives. High reaction yields are obtained for primary, secondary, and tertiary carboxylic acids.  This reagent/method also enables facile decarboxylation of previously challenging substrates while tolerating the presence of other functional groups. This synthetic approach represents a general platform for a range of decarboxylative transformations via the synthetic versatility of xanthate intermediates.  

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