Office of Commercialization and Economic Development
Office of Technology Commercialization

Chimeric Antigen Receptor (CAR) That Increases T Cell Metabolism and Lifetime

Technology #18-0109

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Researchers
Lishan Su
Managed By
Kyle Bartholomew
Commercialization Manager 919.962.5921

A novel chimeric antigen receptor (CAR) that increases CAR-T cell function has been engineered. Typically, a CAR is comprised of a targeting ligand capable of binding to a specific antigen, and at least one co-stimulatory signal domain (CSSD), such as 4-1BB or CD28, that enhances T cell effector functions. We have developed a new CSSD derived from the herpes virus mediator (HVEM) protein, which shows enhanced effector functions, and reduced levels of exhaustion when compared to 4-BB or CD28 CSSDs. We have demonstrated that CAR-T cells that incorporate the HVEM domain have improved activities in a solid tumor mouse model.

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