Office of Commercialization and Economic Development
Office of Technology Commercialization

Luminal Bladder Cancer Cell Lines

Technology #18-0020

We have generated a novel GEM (Genetically Engineered Murine) Model of luminal bladder cancer, called UPPL, by knocking out Pten
and Trp53 in Upk3a expressing cells (Upk3a-CreERT2). Once bladder tumors formed, cell lines were generated that can be passaged
in vitro as well as form tumors in immunocompetent B6 mice

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