Office of Commercialization and Economic Development
Office of Technology Commercialization

Epitope and Antibody for Prevention of Zika and Dengue Viruses

Technology #17-0061

Questions about this technology? Ask a Technology Manager

Download Printable PDF

Ralph Baric
Managed By
Kyle Bartholomew
Commercialization Manager 919.962.5921
Patent Protection
US Patent Pending US 2019/0023745

An epitope that can elicit broadly neutralizing antibodies against Zika virus (ZIKV) and dengue virus (DENZ) has been developed. ZIKV and DENV are endemic in South America and elsewhere, and can lead to fetal malformations, neurological disease and death. Rather than providing protection, generation of cross-reactive antibodies against only one serotype of DENV can increase the severity disease in dengue patients exposed to other serotypes, complicating efforts to develop pan-dengue vaccines. Our researchers have developed an epitope that is shared by ZIKV and DENZ that can elicit an antibody that provides protection against ZIKV and multiple DENV serotypes. This epitope can be used as part of a vaccine that broadly targets both ZIKV and DENV.

Related Publications: