An epitope that can elicit broadly neutralizing antibodies against Zika virus (ZIKV) and dengue virus (DENZ) has been developed. ZIKV and DENV are endemic in South America and elsewhere, and can lead to fetal malformations, neurological disease and death. Rather than providing protection, generation of cross-reactive antibodies against only one serotype of DENV can increase the severity disease in dengue patients exposed to other serotypes, complicating efforts to develop pan-dengue vaccines. Our researchers have developed an epitope that is shared by ZIKV and DENZ that can elicit an antibody that provides protection against ZIKV and multiple DENV serotypes. This epitope can be used as part of a vaccine that broadly targets both ZIKV and DENV.
- Dengue Virus Envelope Dimer Epitope Monoclonal Antibodies Isolated from Dengue Patients Are Protective against Zika Virus. MBio. 2016 Jul 19;7(4). pii: e01123-16. doi: 10.1128/mBio.01123-16.