Noroviruses, human pathogens associated with about 85% of viral gastroenteritis, are genetically and phenotypically distinct. Divided into two large genoclusters designated GI and GII and subdivided into 8 GI genoclusters and 17 GII genoclusters, this high degree of antigenic variation complicates diagnostic and therapeutic design. These mouse monoclonal antibodies target different GI and GII strains of human noroviruses and display broad cross-reactive reactivity patterns. The antibodies may provide superior detection capabilities of more standard subsets of monoclonal antibodies.
These monoclonal antibodies are available from Main Biotechnology Services at http://mainebiotechnology.com/mab227p/ and http://mainebiotechnology.com/mab228p/.
- Norovirus GII.4 strain antigenic variation J Virol 2011 Jan;85(1):231-42