Nlrp1b encodes a pattern recognition receptor that is involved in the formation of the inflammasome, which regulates the immune system’s response to injury, toxins, and infection by cleaving interleukin (IL)-1β. Nlrp1b is specifically activated upon sensing the anthrax lethal toxin and the resulting release of pro-inflammatory cytokines aids in the clearance of the anthrax infection. Homozygous Nlrp3-deficient mice are viable and fertile. Bone marrow derived macrophages from these Nlrp1b-/- mice are not sensitive to anthrax LT challenge. These mice are able to form the inflammasome and activate caspase-1. Caspase-1 activation in these mice leads to pyroptosis, which results in acute lung injury and morbidity within 3 days of infection.
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- NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice J Immunol 2012 Aug 15;189(4):2006-16