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Composition of a Nanoparticle for Gene Delivery in Animals

Technology #09-0134

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Researchers
Leaf Huang
Managed By
Champ Gupton
Commercialization Manager 919.966.4132
Patent Protection
US Patent US 9937128

A novel nanoparticle (NP) formulation that shows enhanced delivery of siRNA to its target cells has been developed. siRNA shows promise as a therapeutic; however, its delivery to its target tissue or cell is often a challenge. We have developed lipid calcium phosphate (LCP) NPs that efficiently deliver siRNAs to their targets. We have demonstrated the ability of these LCP NPs to deliver intact siRNA to target cells in a xenograft model. Additionally, these LCP NPs show little to no immunotoxicity.
 

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