A novel nanoparticle (NP) formulation that shows enhanced delivery of siRNA to its target cells has been developed. siRNA shows promise as a therapeutic; however, its delivery to its target tissue or cell is often a challenge. We have developed lipid calcium phosphate (LCP) NPs that efficiently deliver siRNAs to their targets. We have demonstrated the ability of these LCP NPs to deliver intact siRNA to target cells in a xenograft model. Additionally, these LCP NPs show little to no immunotoxicity.
- Novel Cationic Lipid That Delivers siRNA and Enhances Therapeutic Effect in Lung Cancer Cells Mol. Pharmaceutics, 2009, 6 (3), 696–705