We replaced the gene for the low density lipoprotein receptor (LDLR) in mice with the human equivalent. LDLR is important for cholesterol clearance from circulation and an elevated plasma cholesterol level is the major risk factor for atherosclerosis and coronary heart disease. These mice can be used to investigate gene-gene and gene-environment interactions that present in human lipid metabolism and heart disease. It can also be used to test therapeutic molecules that interact with human LDLR-mediated lipid clearance.
These mice are available at The Jackson Laboratory and can be found at https://www.jax.org/strain/012307.