The neural cell adhesion molecule (NCAM) controls diverse aspects of axon and dendritic development, synaptogenesis, and plasticity. Transgenic mice that express the NCAM-EC fragment from the neuron-specific enolase (NSE) promoter circumvent the early embryonic lethality of mice expressing secreted NCAM generated by a genetic knock-in approach. These mice may reflect the brain expression of NCAM in schizophrenia, in which transmembrane and soluble forms of NCAM are present, and the level of the NCAM-EC fragment is 50% that of NCAM180 and NCAM140. The mice also displayed abnormal behaviors that included deficits in sensory gating and emotional memory as well as alterations in motor performance.
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- Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior J Neurosci 2005 May 4;25(18):4659-71.