Office of Commercialization and Economic Development
Office of Technology Commercialization

Mouse: 5-Lipoxygenase-Activating Protein (FLAP) Null

Technology #05-0105

5-lipoxygenase-activating protein (FLAP) is involved in the synthesis of leukotrienes.  Under certain conditions, FLAP knockout mice exhibit reduced inflammatory response, edema, response to platelet-activating factor-induced shock, and collagen-induced arthritis.  These mice can be used to investigate FLAP modulators and their effect on any of the aforementioned conditions.

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