Life Sciences » Drug Delivery
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Ultra-Long-Acting Implantable Drug Delivery System
18-0089 – HIV continues to be a serious global public health issue and is one of the leading causes of death worldwide. While there is no cure for HIV, antiretroviral therapy remains effective at controlling the virus and preventing transmission to other people. Antiretroviral drugs are used in the prevention and treatment of HIV and are often used in combination to combat against resistance to any one... Read More
Biocompatible film for localized treatment of vulvar pain disorders
19-0083 – Background Vulvodynia is a chronic pain disorder characterized by vulva burning and soreness in the absence of a skin condition, infection, or external factors. Vestibulodynia is specifically pain felt on touch at the opening of the vagina, otherwise symptoms are absent. Pain is commonly described with insertion of a tampon or vaginal penetration, such as with sexual intercourse. It is... Read More
Ultrasound Mediated Delivery of Therapeutics and Disruption of Drug Resistant Biofilms
20-0102 – Background Biofilms are aggregates of microorganisms embedded in a self-produced extracellular matrix and can attach to each other or to surfaces, including a patient’s skin or soft tissue, or an implanted medical device, such as a catheter. Microorganisms that make up biofilms can include bacteria, fungi, and protists. Biofilms are prevalent in many infections and are resistant to... Read More
Brain Infusion System Safety Sheath
19-0045 – Convection enhanced delivery (CED) is a method for delivering therapeutics across the blood-brain barrier to the brain and central nervous system. CED can be used to treat various disease, including brain tumors, Parkinson’s disease, and Alzheimer’s disease, and is generally characterized as a minimally invasive technique. While CED has shown some promise in clinical applications, the current... Read More
Nanofibers for targeted treatment of aortic aneurysms
20-0042 – Background Abdominal aortic aneurysm (AAA), occurs when there is an enlarged portion of the abdominal aorta, and accounts for approximately 10,000 deaths per year in the United States. Current treatments include surgical intervention or minimally invasive laparoscopic repair. However, the AAA can rupture, and the patient will not survive surgery or sometimes even reach the hospital. There are... Read More
Nanofibers for targeted treatment of pulmonary disease
20-0070 – Background Pulmonary hypertension is a progressive and severe condition with severe, and often fatal, consequences. Despite remarkable therapeutic advancements over the last thirty years, mortality rates remain as high as 40%. Current therapies largely target the major regulatory pathways involved in vascular tone. These therapies are associated with considerable limitations such as, a short... Read More
Nano co-delivery of quercetin and alantolactone for colorectal cancer treatment
19-0065 – Quercetin (Q) and alantolactone (A) are two traditional Chinese medicines that have shown a wide spectrum of medical benefits, such as anti-inflammatory and anti-tumor activities. A micelle-based nano-formulation was used to encapsulate these two drugs in a unique ratio (Q:A = 1:4) and to achieve drug delivery to colorectal cancer site, providing optimal drug pharmacokinetics and synergistic... Read More
Composition of a Nanoparticle for Gene Delivery in Animals
09-0134 – A novel nanoparticle (NP) formulation that shows enhanced delivery of siRNA to its target cells has been developed. siRNA shows promise as a therapeutic; however, its delivery to its target tissue or cell is often a challenge. We have developed lipid calcium phosphate (LCP) NPs that efficiently deliver siRNAs to their targets. We have demonstrated the ability of these LCP NPs to deliver... Read More
Functionalized Poly-oxazoline Drug Delivery
19-0121 – A novel poly(2-oxazoline) based polymer functionalized with the condensed form of N, N-dimethylbiguanide (cBOx) has been developed. cBOx was synthesized via the condensation of N, N-dimethylbiguanide with the methyl ester side chain in poly (2-methoxycarboxyethyl-2-oxazoline) of the diblock copolymer composed of poly(2-methyl-2-oxazoline) and poly (2-methoxycarboxyethyl-2-oxazoline). The new... Read More
Nano-Puerarin Formulation for the regulation of the tumor microenvironment
19-0070 – Puerarin is one of several known isoflavones and it has been identified to effectively downregulate ROS production. The targeted nano-formulation delivers puerarin to tumor associated fibroblasts (TAFs) to deactivate tumor stromal microenvironment, allowing for facilitated chemotherapy and immunotherapy effect. It has been found that tumor stromal microenvironment serves as a physical... Read More
Nanofiber-based immunotherapeutic drug delivery specifically targeted to the atherosclerotic niche
18-0152 – A nanodrug delivery system has been developed which precisely targets controlled immunotherapeutics to the atherosclerotic niche. This system is comprised of therapeutic peptides tethered to nanofibers which self-assemble from peptide amphiphiles. These complexes are targeted specifically to atherosclerotic lesions. In addition to its specificity, the nanofiber-based delivery system stands... Read More
Direct Fluorine-18 Radiolabeling of Complex Molecules for Diagnostic and Drug Discovery Applications
17-0133 – A new, facile strategy for labeling medically relevant compounds with fluorine-18 (18F) has been developed which opens the door to both the creation of new PET imaging agents and a deeper understanding of the in vivo fates of drug candidates. Using metal-free organic photoredox catalysis, radioactive 18F is easily incorporated into a wide variety of aromatic and heteroaromatic compounds. This... Read More
Methods of Acoustic Measurement and Control of Pharmaceutical Sprays
04-0112 – Researchers at the University of North Carolina at Chapel Hill have developed a means to correlate acoustic measurements to spray formation, using that relationship to characterize output spray behavior. The technology uses real-time algorithms to impart disruptive energy to the orifice delivering the spray, in this way the technology can modulate spray formation with the intent of... Read More
Coated filament for evaporation/condensation aerosol generation of therapeutic agents and methods
04-0113 – Researchers at the University of North Carolina at Chapel Hill have developed an aerosol generator device for the delivery and administration of therapeutic agents to the lungs. The technology provides a tunable delivery method capable of generating aerosols at precise particle sizes and at a wide range of flow rates.
Method for the Inhibition of Anti-PEG Antibodies
18-0025 – A method for inhibiting the action of anti-PEG antibodies (APAs) has been developed, with the goal of enhancing the effectiveness of PEGylated proteins and nanoparticle therapeutics. APAs can be induced by PEGylated therapeutics, or they can be pre-existing due to previous exposure to PEG in everyday hygiene and food products. The presence of circulating APAs can render PEGylated therapeutics... Read More
Composition of Novel Cationic Nanoparticles for the Delivery of siRNA Therapeutics in Lung Cancer
08-0038 – Cationic nanoparticle formulations have been developed for the delivery of siRNA to tumor cells. siRNA therapeutics are promising treatments for many diseases, but they require delivery vehicles to efficiently transport them to their target cell. We have developed a cationic nanoparticle formulation that efficiently delivers siRNA to H460 human lung carcinoma cells. These nanoparticles were... Read More
Composition and Method for Platelet-Based Drug Delivery
00-0110 – A novel method of drug delivery utilizing rehydrated platelets has been developed. Platelets have long been recognized as potential drug delivery vehicles; however, the need to freshly isolate, modify, and reinfuse them in a short time-span has limited their applicability. Cryopreserved and normally-liquid stored platelets circumvent these problems, but suffer from storage issues and the need... Read More
Use of Tardigrade Proteins to Stabilize Biological Materials, Industrial Enzymes, and Agricultural Products
16-0158 – The instability of many high value industrial enzymes and life saving biologics, including vaccines and protein-based pharmaceuticals, require that such materials be produced, transported and stored under refrigerated conditions, which adds difficulty and expense. Lyophilization is an alternate storage method that allows some pharmaceuticals to be stored at room temperature. Unfortunately,... Read More
Exosomal Drug Delivery for Chemotherapy and CNS Disorders
16-0102 – Novel exosome-based compositions have been developed for the delivery of low molecular weight active ingredients, drugs and macromolecular biotherapeutics to sites of disease associated with inflammation including tumors and the central nervous system. When derived from individual patient exosomes, these vesicles have immune-privileged status which allows them to deliver therapeutic agents to... Read More
Poly-Metformin: A Polymeric Formulation for the Treatment of Metabolic Disorders and Enhanced Gene Delivery
15-0060 – A polymeric formulation of Metformin has been developed. PolyMetformin (PolyMet) has been successfully synthesized through conjugation of linear polyethylenimine (PEI) with dicyandiamide. The delocalization of cationic charges in the biguanide groups of PolyMet reduces the toxicity of PEI both in vitro and in vivo. Furthermore, the polycationic properties of PolyMet permit capture of siRNA... Read More
Next Generation Biomedicine Low Frequency Magnetic Nanoparticles
15-0061 – Novel polymer-coated magnetic nanoparticles (MNP-polymer complexes) have been developed that can be used in a variety of biomedical, therapeutic, and industrial applications. The iron oxide magnetic nanoparticle cores are synthesized by thermal decomposition yielding a tunable, uniform size. These unique polymer coatings have been shown to promote enhanced uptake into tumor and other cells.... Read More
Delivery of Neuroprotective Therapeutic Agents to the CNS
15-0104 – Innovative polymer-based formulations have been developed for delivery of neurotrophins to the brain using peripheral and central administration. The anionic block copolymers are used in charge excess with respect to the neurotrophins, so that neurotrophins and block copolymers form a nanoscale size polyion complex, while the free block copolymers are also present in the formulation. The... Read More
Optimal PEG Coating of Particles for Minimizing Uptake and Clearance of Nanoparticle Therapeutics
13-0118 – Nanoparticles with tunable poly(ethylene glycol) (PEG) grafting have been used to determine optimal PEG coating for minimizing immune uptake and clearance. PEG is widely used to improve nanoparticle retention in circulation. Quantitative measurement of surface PEG grafting is difficult for determining the specific amount needed to coat particles to evade uptake and clearance by immune cells.... Read More
Biodegradable Elastomers for Medical Devices and Drug Delivery
06-0047 – Amorphous, polyester-based elastomers have been developed with tunable thermal and mechanical properties for applications in tissue engineering and drug delivery. Synthetic materials for biological applications must have similar mechanical properties to those of surrounding tissue to minimize irritation. Commonly used polymers suffer from rapid loss of mechanical properties upon degradation... Read More
Decision Support System for Intravenous Insulin Infusion with Cross-Step Estimator of Maintenance Rate
07-0042 – A system for determining an intravenous insulin infusion rate to correct hyperglycemia of a patient Advantages: • Reduces the risk of hyper/hypoglycemia • Allows the user to assign a glycemic target • Controls glycemic variability above the glycemic target by a strategy different from the insulin strategy used to control variability below the glycemic target • Takes into account the... Read More