Life Sciences

1-50 of 211 technologies within Life Sciences RSS ATOM

Nano-Puerarin Formulation for the regulation of the tumor microenvironment

19-0070 – Puerarin is one of several known isoflavones and it has been identified to effectively downregulate ROS production. The targeted nano-formulation delivers puerarin to tumor associated fibroblasts (TAFs) to deactivate tumor stromal microenvironment, allowing for facilitated chemotherapy and immunotherapy effect. It has been found that tumor stromal microenvironment serves as a physical... Read More

Liposomal hydralazine that promotes nanoparticle penetration in desmoplastic tumor

19-0076 – Hydralazine (HDZ) is vasodilator commonly used to treat high blood pressure and heart failure. The targeted liposomes deliver HDZ to tumor stromal cells to locally vasodilate blood vessels in the tumor, allowing for enhanced nanoparticle penetration and following chemotherapy or immunotherapy effect. Nanoparticle-mediated drug delivery holds great promise for cancer treatment. However, the... Read More

Mouse: Ccdc8 KO

20-0031 – To determine the mechanism underlying the 3-M syndrome, we knocked out Ccdc8 in the C57BL/6J mouse strain by standard homologous recombination methods. Ccdc8 conditional and conventional mice were generated by gene targeting in ES cells from C57BL/6 background strain microinjected into albino-C57BL/6 blastocysts. Successful Ccdc8 knockout was confirmed by Southern, PCR and DNA sequence.... Read More

Luminal Bladder Cancer Cell Lines

18-0020 – We have generated a novel GEM (Genetically Engineered Murine) Model of luminal bladder cancer, called UPPL, by knocking out Pten and Trp53 in Upk3a expressing cells (Upk3a-CreERT2). Once bladder tumors formed, cell lines were generated that can be passaged in vitro as well as form tumors in immunocompetent B6 mice Related Publications:

Software for the Analysis of Electrocochleograms

20-0019 – The Electrocochleogram (ECochG) is an electrophysiologic signal acquired from the cochlea in response to sound or electrical stimulaton. This recorded signal is a mixture of potentials generated by hair cells and nerve activity. Although many companies make products which can acquire the ECochG signal, the interpretation of that signal is largely qualitative. Our investigators have developed... Read More

Synthetic Peptide Mimetic for the Treatment of Rare Hematalogical Disorders

19-0178 – We have recently developed a cell penetrating, synthetic peptide for the treatment of cancer, sickle cell anemia and ß-thalassemia, that disrupts the MBD2:NuRD complex in human cells. This is based on the observation that enforced expression of a small peptide from the GATAD2A protein could disrupt complex formation and block DNA methylation, making this peptide a potential alternative to... Read More

Biologically Targeted Photo-Crosslinkable Nano-Patch to Prevent Postsurgical Peritoneal Adhesion

18-0101 – A biologically targeted, photo-crosslinkable nanopatch (pCNP) that prevents postsurgical adhesion has been developed. Peritoneal adhesion occurs in a majority of patients following abdominal surgery and can result in significant side effects and complications. Current strategies to minimize adhesions involve the use of nontargeted anatomical barriers that are either inefficient in protecting... Read More

Small Molecules for the Treatment of Central Nervous System Disorders

10-0118 – Small molecules that can bind dopamine receptor D2 have been developed for the treatment of central nervous system (CNS) disorders. The compounds developed have both agonist and antagonist activity and were proven effective in in vitro and in vivo models. Significantly, in hyperlocomotion mouse models, these compounds showed efficacy and potency without inducing catalepsy. These compounds can... Read More

Advanced Colonoscopy Imaging Technology

19-0148 – Colonoscopy reduces the rate of colorectal cancers following colonoscopy (interval cancers) by 50-60%. However, colonoscopy fails to find at least 20% of polyps, especially “flat” polyps. Polyps are missed because not all of the colon surface is effectively surveyed by current visualization systems or the polyps were seen but not effectively recognized by the current imaging technology. This... Read More

Assessing Lower Extremity Movement Quality

18-0003 – Clinical assessment tools can provide a simple and efficient method for identifying problems in the musculoskeletal system that may result in athletic injury. Sports medicine clinicians can often use the results of such assessment tools to develop effective intervention programs for injury prevention and rehabilitation. This innovation provides an objective and autonomous system to classify... Read More

Chimeric Antigen Receptor (CAR) That Increases T Cell Metabolism and Lifetime

18-0109 – A novel chimeric antigen receptor (CAR) that increases CAR-T cell function has been engineered. Typically, a CAR is comprised of a targeting ligand capable of binding to a specific antigen, and at least one co-stimulatory signal domain (CSSD), such as 4-1BB or CD28, that enhances T cell effector functions. We have developed a new CSSD derived from the herpes virus mediator (HVEM) protein,... Read More

Small Molecule Mutant IDH1 Inhibitors Useful for Treating Cancer

16-0001 – Small molecule inhibitors of mutant Isocitrate dehydrogenase 1 (IDH1) have been developed for the treatment of cancer. Normal IDH1 converts isocitrate into ketoglutarate. A mutated form of IDH1 is found in several cancers including glioma, cholangiocarcinoma, and acute myeloid leukemia. Expression of mutated IDH1 leadd to elevated levels of R-2-hydroxyglutarate (2HG). 2HG has been linked to... Read More

Cell Line: AALEB

19-0116 – AALEB is an engineered cancer cell line, which was prepared from primary human bronchial epithelial cells that were serially transformed by retorvial driven expression of SV40 early region genes, human telomerase reverse transcriptase, and selection markers. Related Publications:

Cell Line: UNCCF7T

19-0150 – This is a growth enhanced cell line derived from primary epithelial cells originally obtained from the explanted lungs of a donor with cystic fibrosis, in accordance with an IRB-approved protocol, that underwent lung transplantation. The CFTR genotype is G542X homozygous, enabling this cell line to be used to study the biology and potential therapies for diseases created by premature... Read More

Use of Aminobisphosphonates as Latency Reversing Agents

18-0151 – Novel methods for the reversal of latency in HIV infected cells, and for the clearance of latently infected cells have been discovered. Aminobisphosphonates (N-BPs) are a class of drug currently FDA approved for the treatment of several diseases involving the loss of bone density. Our investigators have demonstrated that N-BPs can reverse latent HIV viruses in infected immune cells without... Read More

Epitope and Antibody for Prevention of Zika and Dengue Viruses

17-0061 – An epitope that can elicit broadly neutralizing antibodies against Zika virus (ZIKV) and dengue virus (DENZ) has been developed. ZIKV and DENV are endemic in South America and elsewhere, and can lead to fetal malformations, neurological disease and death. Complicating the efforts to develop vaccines is the fact that the generation of cross-reactive antibodies against only one serotype of DENV... Read More

Repurposing Dabuzalgron to Prevent and Treat Cardiomyopathy and Heart Failure

15-0105 – Dr. Paul Simpson Jr. at University of California, San Francisco and Dr. Brain C Jensen at University of North Carolina - Chapel Hill have identified and developed a new indication for dabuzalgron: prevention and treatment of cardiomyopathy and heart failure. Dabuzalgron is an alpha-1A- adrenergic receptor agonist that can stimulate smooth muscle contraction in higher doses; however, in this... Read More

Reconstructing Detailed Textured Surface Models from Endoscopic Videos

18-0149 – A method has been developed for constructing an accurate three-dimensional textured surface from an endoscopic video, and for transferring information from the reconstruction onto images gathered through other modalities such as computed tomography (CT). This technology facilitates more efficient and thorough review by clinicians and researchers and has demonstrated usefulness in planning... Read More

Gamma Secretase Inhibitors Attenuate Vascular Malformations

16-0192 – Gamma secretase inhibitors (GSI) have been determined to attenuate vascular malformations by inhibiting NOTCH expression in endothelial cells. Vascular malformations are developmental abnormalities of venous, arterial, capillary or lymphatic vessels which have significant morbidities such as pain, infection, pulmonary emboli, bleeding and even death. There is growing interest in medical... Read More

Recombinant Antigens for Differential Serological Detection of Remote Zika Infection

18-0017 – Two novel antigens have been developed for the serological diagnosis of Zika virus. Accurate diagnosis of Zika is critically important to its treatment, prevention, and further clinical research. Antibodies raised in response to other flaviviruses are often cross reactive to Zika virus, complicating serological diagnosis. These novel recombinant antigens demonstrate lower cross reactivity as... Read More

Highly Specific and Neutralizing Therapeutic Antibodies for Zika Virus

18-0023 – Our investigators have identified two highly specific and neutralizing antibodies isolated from a traveler naïve to all serotypes of Dengue. The antibodies (A9E and G9E) can be used against 7 different Zika virus types and react only to Zika virus and no other flaviviruses. Applications: •Diagnosis and treatment of Zika virus infection. •Antibody sequences for vaccine development. ... Read More

AAV-Based Gene Therapy for Equine Osteoarthritis

17-0041 – An AAV-based gene therapy has been developed to treat equine osteoarthritis (OA). Interleukin receptor antagonist protein (IL-1ra) blocks joint inflammation caused by IL-1b stimulated cells, and for this reason, it has shown promise in the treatment of OA. Our OA gene therapy cassette utilizes an optimized self-complimentary AAV to produce significant levels of IL-1ra in vivo. In equine... Read More

Light Triggered CRISPR/Cas9 for Spatial and Temporal Control of Genome Editing

16-0095 – A novel, light-activated Cas9 protein has been developed for better special and temporal control of the CRISPR/Cas9 gene editing system. The addition of a caged lysine residue keeps Cas9 dormant by default, but in the presence of light the lysine caging group falls off and Cas9 springs into action. Unlike standard CRISPR/Cas9, which has full reign over the body, our light-activated system... Read More

BALB/c Latency Mouse Line

19-0023 – BALB/c mice are commonly used for B cell hybridoma development because of their predictable B cell responses to various antigens. Our investigators have developed the tg801 transgenic mouse line, (BALB/c latency mice), as an alternative to the commonly used BALB/c or BALB/c/FcgR2b KO mouse that are often used for hybridoma development. Our mouse line was created via random insertion of a... Read More

Wnt1 as a Therapeutic to Enhance Cardiac Repair and Increase Blood Flow in Patients with PVD

11-0002 – Wnt-1 has been identified as a potential new therapeutic agent to enhance cardiac repair in patients with heart ailments, and to increase blood flow in patients with peripheral vascular disease. Following acute cardiac injury, Wnt1 orchestrates a critical early repair response and disruption of downstream Wnt1 signaling leads to heart failure and death. Furthermore, studies in mice show that... Read More

Image Analysis with Deep Learning For Molecular Subtyping of Breast Cancer

19-0010 – RNA-based, multi-gene molecular assays are available and widely used for patients with ER-positive/HER2-negative breast cancers. However, RNA-based genomic tests can be costly and are not available in many countries. Methods for inferring molecular subtype from histologic images may identify patients most likely to benefit from further genomic testing. To identify patients who could benefit... Read More

Conserved Epitopes for Vaccination Against GII.4 Norovirus Strains

17-0144 – Antigenic diversity within the GII.4 genotype of human norovirus is a significant hurdle to the development of cross-protective immunity after natural infection and vaccination. Our investigators have developed a method of identifying conserved GII.4 norovirus epitopes. Using this method, a conserved GII.4 antibody epitope and residues that mediate antibody access to this conserved epitope... Read More

MTAP Inhibitors for Treatment of Airway Inflammation Associated with CF and COPD

16-0020 – Small molecules have been identified that decreases inflammation associated with cystic fibrosis (CF) and COPD. Accumulation of the metabolite 5’-methylthioadenosine (MTA) promotes an anti-inflammatory response. However, the direct administration of MTA is not a viable therapeutic strategy due to poor pharmacokinetics. The small molecules we developed increase endogenous MTA levels by the... Read More

Using phase-changing nanodroplets to dissolve blood clots with ultrasound

18-0123 – Thrombosis, or pathologic blood clot formation, causes many vascular diseases. UNC researchers have developed a new method for using ultrasound to dissolve blood clots which improves on existing thrombosis treatment practices. The technique combines ultrasound with use of nanodroplets which convert from liquid to gas when exposed to ultrasound energy. This phase change enhances the disruption... Read More

Nanofiber-based immunotherapeutic drug delivery specifically targeted to the atherosclerotic niche

18-0152 – A nanodrug delivery system has been developed which precisely targets controlled immunotherapeutics to the atherosclerotic niche. This system is comprised of therapeutic peptides tethered to nanofibers which self-assemble from peptide amphiphiles. These complexes are targeted specifically to atherosclerotic lesions. In addition to its specificity, the nanofiber-based delivery system stands... Read More

Long-acting injectable multipurpose implants for treatment of osteoporosis

18-0167 – Osteoporosis, a chronic disease associated with a decrease in bone strength and increase in bone fractures, leads to high rates of morbidity and mortality globally. UNC researchers have developed a novel long-acting, multipurpose implant as a treatment option for osteoporosis which is safer, more effective, and more versatile than current first-line therapies for osteoporosis which require... Read More

Improved removal of stimulation artifacts in intracranial electroencephalography

18-0136 – Cortical oscillations are associated with key cognitive functions and show impairment in many psychiatric disorders. They are most effectively measured using direct cortical stimulation (DCS) in intracranial electroencephalography (iEEG). A new algorithm has been developed to remove artifacts caused by DCS when recording iEEG signal. This technique, which has been validated on simulated and... Read More

Novel PET tracers for predicting tumor response to immunotherapy

17-0028 – Labeled Positron Emmision Tomography (PET) imaging tracers have been developed which can easily screen tumors for responsiveness to specific immunotherapies. This low-cost screening method prevents application of costly immunotherapy to non-responsive tumors. These novel tracers are also relevant to serotonin pathways important in diabetes and neurophysiology. Advantages:

Direct Fluorine-18 Radiolabeling of Complex Molecules for Diagnostic and Drug Discovery Applications

17-0133 – A new, facile strategy for labeling medically relevant compounds with fluorine-18 (18F) has been developed which opens the door to both the creation of new PET imaging agents and a deeper understanding of the in vivo fates of drug candidates. Using metal-free organic photoredox catalysis, radioactive 18F is easily incorporated into a wide variety of aromatic and heteroaromatic compounds. This... Read More

Combined Acoustic Radiation Force Impulse (ARGI) Ultrasound and Elastography for Improved Tissue Imaging

12-0104 – Acoustic Radiation Force Impulse (ARFI) ultrasound is a tissue imaging method where a short duration impulse (on the order of microseconds) of relatively high acoustic energy is transmitted into the body. The tissue’s response in terms of its peak displacement and subsequent recovery from displacement is used as an indicator of the tissue’s mechanical properties. The use of ARFI for... Read More

Increased Recombinant AAV Vector Yield Using Engineered Assembly Activating Proteins

18-0116 – Assembly Acting Proteins (AAPs) are required for adeno-associated viruses (AAVs) capsid formation. Novel engineered Assembly Activating Proteins (eAAPs) have been developed with enhanced stability that promote viral assembly and enhance vector yields of recombinant AAV by 200% over wildtype AAP. eAAPs can address some of the manufacturing limitations of AAV needed for gene therapy, gene... Read More

Novel Cross-Linker and Related Methods of Isotope Tagging for Analysis of Protein Interactions

13-0034 – An isotope labeled cross-linker has been developed to improve the detection of cross-linked peptides. Chemical cross-linking is often used to study protein-protein interactions, however gas-phase dissociation reactions of cross-linkers often lack the sensitivity and specificity to fragment the cross-linker at the desired location. Consequently, there is a need for improved cross-linkers for... Read More

Topical Tigecycline to Control Endodontic Infections

18-0031 – Endodontic infections result from a variety of bacteria and require treatment, which can include tooth extraction. The severity of infection can lead to hospital stay, morbidity, and even mortality, if not cared for properly. Though antibiotics are ideal, some bacteria have developed a resistance, as a result of antibiotic use in both medicine and dentisty. Tigecycline is a promising... Read More

Side-car Bassinet to Improve Mother and Baby Development Post-delivery

17-0003 – A side-car bassinet particularly designed for U.S. maternity beds may improve mother-baby development post-delivery. The bassinet locks into maternity beds, when proximity to mother is warranted, but can be disengaged, and converted to a stand-alone bassinet. To promote breast-feeding in the hours after delivery, it is understood that keeping mother and baby together is important. Stand-alone... Read More

Novel System for Personalized Brain Stimulation to Alleviate Deficiencies in Higher Order Cognitive Function Cloud Infrastructure

17-0050 – A novel system that provides targeted and personalized brain stimulation to increase sleep spindle oscillations to alleviate deficiencies in higher order cognitive function, allowing for the treatment of psychiatric and neurological impairments. This technology is cloud infrastructure to support transcranial current stimulation device.

Novel System for Personalized Brain Stimulation to Alleviate Deficiencies in Higher Order Cognitive Function Software

17-0051 – A novel system that provides targeted and personalized brain stimulation to increase sleep spindle oscillations to alleviate deficiencies in higher order cognitive function, allowing for the treatment of psychiatric and neurological impairments. This technology is the firmware written to control transcranial current stimulation device. This piece of software controls the delivery and... Read More

Higher Frame Rate Ultrasound Imaging for Improved Detection of Human Physiological Events

17-0062 – Ultrasound imaging at high frame rates (50 Hz or greater) is reliant on plane-wave transmission. Unfortunately, high frame rate imaging is not conducive with compounding, or averaging, of different acoustic signals to improve image quality. With every ultrasound transmit being devoted to image quality, that is one transmission being lost for analysis of temporal changes in the image. As the... Read More

Device and Method for Improving Motor Memory and Other Cognitive Functions, a Potential Therapy for Alzheimer’s Disease, Schizophrenia, Autism and ADHD

16-0010 – Research in understanding the role thalamo-cortical oscillations, like sleep spindles, play in cortical network dynamics and cognitive processes in humans has been impeded due to a lack of tools to monitor and selectively enhance rhythmic brain activity in real-time. Further, current treatment options for these disease aim only to help prolong functional capabilities and slow symptom... Read More

Improved Mechanical Imaging for Internal Organs and Muscles

16-0098 – Acoustic radiation force impulse (ARFI) imaging is a technique that utilizes ultrasound to characterize the viscoelastic property of tissue. It is understood that certain organ systems have directionally dependent characteristics (property known as anisotropy). Disease progression may change the mechanical response of tissue, and the ability to measure these changes along multiple axes is... Read More

Detection of Brain Motion with High-frame Rate Ultrasound Imaging

16-0141 – There is a lack of understanding of the mechanisms at work during a traumatic brain injury (TBI). Though brain motion has been extensively linked to TBI, direct quantifiable measurements are absent, which could aid in progressing understanding and diagnosis of TBI. The Pinton lab has developed an ultrasonic method for detecting the motion of the brain, at frame rates as high as 10,000 images... Read More

Periodontal Profile Class Scoring Model to predict tooth loss and oral disease progression

16-0170 – University of North Carolina Researchers have developed a new application of the latent class analysis (LCA) method to identify groups of patients with differing classes of periodontal disease. This method uses LCA to create classes using clinical indices typically used in a dental exam derived from a dataset of over 6,900 community dwelling subjects. The model defines 7 classes of... Read More

Adrenomedullin Therapy to Improve Fetal Implantation

15-0097 – Researchers at the University of North carolina have developed a short-term treatment of mouse uterine lining with adrenomedullin peptide prior to pregnancy to improve fetal implantation numbers and overall quality of implantation. This simple, cost-effective and minimally-invasive procedure could be used to improve the success of assisted reproductive technologies in humans, which were... Read More

Combined Acoustic Radiation Force Impulse (ARGI) Ultrasound and Elastography for Tissue Imaging

08-0050 – Acoustic Radiation Force Impulse (ARFI) ultrasound is a tissue imaging method where a short duration impulse (on the order of microseconds) of relatively high acoustic energy is transmitted into the body. The tissue’s response in terms of its peak displacement and subsequent recovery from displacement is used as an indicator of the tissue’s mechanical properties. The use of ARFI for... Read More

Methods of Acoustic Measurement and Control of Pharmaceutical Sprays

04-0112 – Researchers at the University of North Carolina at Chapel Hill have developed a means to correlate acoustic measurements to spray formation, using that relationship to characterize output spray behavior. The technology uses real-time algorithms to impart disruptive energy to the orifice delivering the spray, in this way the technology can modulate spray formation with the intent of... Read More

Coated filament for evaporation/condensation aerosol generation of therapeutic agents and methods

04-0113 – Researchers at the University of North Carolina at Chapel Hill have developed an aerosol generator device for the delivery and administration of therapeutic agents to the lungs. The technology provides a tunable delivery method capable of generating aerosols at precise particle sizes and at a wide range of flow rates.

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