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17-0083 – Mutations in cryopyrin (NLRP3), a large protein functioning as an important immune pathway in human disease, have been identified in most patients with autoinflammatory disorders. The severity of the disease is likely related to the degree a particular mutation alters the protein. This mouse line, in which the NLRP3 locus has been excised and replaced with its human counterpart, shows value... Read More
17-0074 – Cryptochrome 1 (Cry1) and cryptochrome 2 (Cry2) proteins are core components of the mammalian circadian rhythm and help keep the circadian clocks in cells in time and in proper rhythm with the 24-hour day, as well as the seasons. Mice mutated in both genes are arrhythmic. This CRY1 hybridoma cell line is derived from Cry1-/-Cry2-/- mice, which allows investigation into cryptochrome knockout... Read More
17-0070 – Increased connective tissue growth factor (CTGF) is associated with fibrosis in chronic organ injury. Studying the role of CTGF in fibrotic disease in vivo, however, has been hampered by perinatal lethality and the limited scope of CTGF mice. In this single mutant mouse strain, replacement with or excision of a modified CTGF allele results in 60% normal CTGF expression (Lo allele) or... Read More
17-0029 – Ovarian tumor (SKOV3) cells transfected with Human Leukocyte Antigen-A2 (HLA-A2).
16-0176 – Antisense oligonucleotide-mediated down-regulation of genes that cause human diseases such as cancer and viral infections has been accomplished in cellular and animal models. Unfortunately, these oligonucleotides in cell culture and in vivo frequently exhibit non-antisense effects due to sequence-dependent as well as non-specific interactions with proteins. In this cell line, antisense... Read More
16-0168 – A new class of two-dimensional materials has been developed for battery electrodes that are derived from bulk electride crystals such as Ca2N, Sr2N, Ba2N, and Y2C. Electrides are materials that trap electrons at stoichiometric concentration, such that the electrons themselves serve as counteranions. Despite rapid progress in the last decade to synthesize, isolate, and use electrides, a... Read More
16-0166 – Damaged DNA binding protein 1 (DDB1) could prevent the replication of damaged DNA, contributing to DNA repair and the maintenance of genomic integrity. These rabbit polyclonal antibodies to DDB1 (N-REKEFNKGPWKQENVE-H) were raised against a synthetic peptide derived from human p127DDB1 coupled to keyhole limpet haemocyanin (KLH). They are useful for evidencing the in vivo association of DDB1... Read More
16-0163 – A welding process for fusing semiconducting nanowires on a large scale to create flexible, electrically-active, macroscopic meshes has been developed. Transparent, free-standing films were fabricated from these welded networks with no significant increase in sheet resistance relative to that of the on-substrate networks. Network formation has been scaled to centimeter size using this... Read More
16-0160 – In neurons, activation of hM4Di induces neuronal silencing. This model can be used to selectively and reversibly suppress hippocampal neuronal activity during synaptic consolidation. Clozapine-N-oxide induces Gi activation and allows in vivo manipulation of neuronal activity in freely moving animals.
16-0159 – Transgenic mice expressing an evolved G protein-coupled receptor (hM3Dq) selectively activated by the pharmacologically inert, orally bioavailable drug clozapine-N-oxide (CNO). Behavioral correlates of neuronal activation included increased locomotion, stereotypy, and limbic seizures.